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Mediso - nanoScan Family

nanoScan Family: the next generation in vivo preclinical imaging platform

Preclinical imagers of the nanoScan Family combine the industry’s highest performing microscopy level of molecular PET and SPECT imaging supported by excellent MRI and CT performance. Mediso has designed a platform that can satisfy the increasing needs of any research institute with shared components and flexible upgrade possibilities.

The ultimate versatility and in-line combinations of the preclinical imaging systems are based on shared hardware and software building blocks, common animal handling platform and easy on-site upgrade possibility, thus fulfill all demands of your growing and long term research requirements. Seven systems avaliable: standalone PET, standalone SPECT, standalone CT, bi-modal PET/CT, bi-modal SPECT/CT, bi-modal PET/MRI, bi-modal SPECT/MRI and triple modality PET/SPECT/CT.

Expending your capabilities for life science research and drug development

SPECT
- 275 µm visible resolution
- over 97%
quantification accuracy
- up to 10,000 cps/MBq
sensitivity by 100 pinholes

 

MRI 3T and 1T
- 100 µm resolution
- low fringe fields
 - can be installed almost anywhere

 

PET
- 700 µm visible resolution
- over 97% quantification
accuracy
- 9% maximal sensitivity

 

CT
- 30 µm resolution
- 80 W X-ray power
- ultra low dose acquisition protocol

Exclusive features only from Mediso's nanoScan® Preclinical Imaging Family

  • Tri-modality combination: PET/SPECT/CT
  • Combinations of two MRI and two CT based bimodal solutions (PET/MRI(3T), PET/MRI(1T), SPECT/MRI, PET/CT, SPECT/CT)
  • Highest visible resolution in Nuclear Medicine modalities: 300 μm SPECT and 700 μm PET
  • Highest PET and SPECT quantification accuracy: over 97% in both modalities
  • Dynamic list mode acquisition for both PET and SPECT
  • Fulfil low to high budget requirements with continuous on-site upgrade path
  • Worldwide exclusive factory support through equipment lifetime (guaranteed for more than 10 years for all systems including NanoSPECT/CT® and NanoPET™/CT)

Use nanoScan for precisely quantified in vivo studies

Key areas: Cancer Biology, Inflammatory Disease/Autoimmune, Neurobiology/CNS/Neurodegeneration, Cardiology or Vascular Biology, Diabetes, Liver Disease, Lung Disease, Urology, and many more...

Main applications: Monitoring Treatment Response, Pharmacokinetics, Pharmacodynamics, ADME, Metabolic Studies, Gene Expression, Protein Expression, Receptor Binding, Toxicology, Cell Tracking and Disease Model Development.

Shared Elements

Mediso Medical Imaging Systems has a robust platform strategy. All products in the preclinical in vivo imaging platform rely strategically on common subsystems and elements to increase the product reliability and user experience, and to decrease the learning curve of the users. Some of the common elements are:

  1. MultiCell Small Animal Environment System
    • Full MRI / SPECT / PET / CT compatibility
    • Closed, temperature controlled system (up-tight container) with transparent cover
    • Embedded anesthetic gas connection: for any isoflurane system through dockable connection to the mouse /rat nose cone
    • 4D/5D imaging accessories: dockable connections for ECG respiratory gating and blood pressure monitoring system
    • Pathogen-free sterile environment for immuno-compromised animals
    • MultiCell Anaesthesia connection with nose coneWidest range of animals are supported:
      • Mouse,
      • Several Rat Sizes,
      • Rabbit,
      • Monkey and
      • Mouse Hotel MultiCell imaging cells are available.
  2. Physiological Monitoring Package (Respiratory/ECG/Temperature)

    • Nucline Acqusition Software: CT Scout View with ECG gatingRespiratory, ECG and temperature signals of the animal are registered real-time to monitor the physiological status of the animal during the scan
    • ECG monitoring module: 3 ECG electrodes, variable gain, 1200 bpm max, ECG waveform and trend display
    • Respiration monitoring module: Pneumatic pillow, Respiration waveform display
    • Temperature monitoring module: rectal probe for continuous monitoring
  3. Physiological Gating Packages (optional)
    • ECG trigger module
    • Respiratory trigger module
    • Additional gating signals
  4. Nucline in persistent scope modeNucline™ All-modality Acquisition Software
    • Common platform for all imaging modalities (SPECT, CT, PET or MR)
    • Developed for multimodal medical imaging devices
    • Integrates a wide range of functionalities of acquisition and calibration, data management, reconstruction and visualization having a uniform user interface.
    • Operates under common industry standards and provides DICOM standard images which are stored in a DICOM server.
  5. Tera-Tomo™ 3D SPECT and PET reconstruction engine Software
    • Using corrections for physical factors such as detector geometry, Continuous Monte Carlo DOI estimation, object attenuation and scatter, randoms and dead time
    • Quantitative three-dimensional SPECT or PET reconstruction developed in collaboration with academic partners
    • Bringing SPECT and PET resolution close to the physical limits
  6. Interview™ FUSION multi-modal application Software

  7. 3rd party software: inviCRO's VivoQuant post-processing analysis and viewing software for image data

  8. DICOM Server Software

  9. State of the art computers and workstations with the latest technologies, like multi GPU image reconstruction, 12TB archiving and 1GB data transfer routes incorporated, supporting both on the fly and post reconstruction at the same time.

Innovation continuously occurs at both the level of the overall architecture as well as the finer level of the individual subsystems and interfaces, bringing the lifecycle development to a new level.