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Mediso - nanoScan PET/MRI

nanoScan PET/MRI

Integrated whole-body preclinical PET/MRI system for in-line imaging

By combining the world's highest-performing PET system with state-of-the-art, compact MRI technology, nanoScan PET/MRI gives you the power to combine soft tissue images with detailed quantitative functional imaging data within just one study. The compact system is easily installed in a day and requires practically zero investment for site preparation. The plug-and-work preclinical system is easy to operate and maintain by life scientists without MRI expertise.

Summary of Key Benefits

  • No compromise in imaging performance1: the negligible fringe field from the permanent magnet ensures superior performance of PET subsystem
    • 700 µm spatial resolution with Tera-Tomo™ 3D PET reconstruction engine with Full Detector Modeling and Attenuation2/Scatter Correction in objects
    • Absolute quantification accuracy over 97%
  • Versatile soft tissue contrast for the best Volume of Interest definitions
    • Determine the volume of tumors: for characterizing the size, vascularization and heterogeneity
    • Detailed structural information in the brain reveals exact distribution of neurological PET tracers
  • Reduced radiation exposure of the animals
    • Anatomical information obtained with non-ionizing radiation (especially important for treatment models)
  • Compact and easy-to-use design
    • does not require special training/education,
    • there is no need for long calibrations after start-up
    • there is no waiting time between PET and MRI acquisitions
    • quick and easy installation

Selected Features for PET subsystem

  • Superior PET detector characteristics: Physical performance matches animal imaging performance
    • High-density, ultra-small detectors in tight packing with finest LYSO detector elements in the industry with smallest pitch
    • Increased crystal thickness for highest sensitivity
  • Measure even the finest details: Tera-Tomo™ 3D PET reconstruction engine brings PET resolution close to the physical limits with outstanding quantification and better signal recovery and signal-to-noise ratio: 
    • Features Monte Carlo system matrix modeling and Depth of Interaction correction; incorporates attenuation1, scatter, positron range, random and dead time corrections
    • Reconstruction running on multiple GPUs (Graphical Processing Units) delivering shorter computational time
  • Perform Acquisition and Reconstruction simultaneously with the powerful workstations including DICOM server and multi-modality display and analysis suite

Summary of Key Benefits for high-performance, compact MRI subsystem

MRI from Aspect Imaging

Compact permanent 1T Magnet

  • No active fringe magnetic field - The PET/MRI can be placed anywhere in a research facility (in a lab, even next to other important imaging systems)
  • Virtually maintenance-free
  • Does not require dedicated facilities or shielded rooms, no isolation from other metal objects, simple siting and no dedicated power supplies or cooling required
  • Easy-to-use software, simple workflow and pre-programmed sequences. Lab technician with no prior MRI or imaging experience can quickly master the platform and perform highly effective MR-based imaging experiments
  • The magnet operates at a 1 Tesla field strength. This is the most suitable field strength and frequency in which to perform gadolinium-based contrast agent imaging due to the nature of the relaxivity curves of such agents
  • Silent operation by whispering gradients – animals can be kept in the same room and depth of anesthesia can be kept at a minimum
  • Image resolution 100 μm in-vivo (ex-vivo spatial resolution <100 µm)

Imaging Performance with Tera-Tomo 3D PET Reconstruction Engine

Advantages of the Compact and Integrated System

  • No loss of information due to reorientation
  • Attenuation & Scatter Correction based on MRI data
  • Common gantry and single image coordinate system for both modalities
  • Common integrated acquisition software
  • Integrated and optimized PET/MRI acquisition protocols
  • PET acquisition and reconstruction range selection based on MRI images
  • Whole-body MRI imaging with up to 240 mm extended axial field of view
  • Unequivocally co-registered MRI volume as anatomical reference for PET studies
  • ECG and Respiratory gated imaging for both PET and MRI modalities

Why Integrated?

Would you buy stand-alone PET and CT systems? Why would an integrated PET/MRI be different?
Want to achieve reproducible, sub-millimetre co-registered fusion of your modalities?

Due to the high level of integration of the nanoScan PET/MRI, there is no loss of information caused by reorientation and co-registration of images acquired on standalone systems.

This design allows accurate attenuation and scatter correction based on MRI datasets which is not possible with standalone or separated systems

(1) due to the inevitable misalignment of the object caused by manual positioning and

(2) due to lack of integration of PET reconstruction and MRI data acquisition.

Automatic co-registration is ensured by single, integrated acquisition software used by the nanoScan PET/MRI imager. Moreover precise positioning and automatic gantry movements enable multiple bed position MRI acquisition covering the entire body length of a mouse or rat.

The temporal correlation is quasi-simultaneous: users do not need to spend time moving the animal from one imager to the other or from one room to another. Switching between PET and MRI acquisitions has never been so quick and easy before.

Considering these advantages of the integrated nanoScan PET/MRI system, it is not surprising that throughput is high: acquiring a PET/MRI image will take about the same amount of time as a PET/CT image taken with a dedicated PET/CT imager.

nanoScan PET/MRI uses the permanent magnet technology from Aspect Imaging which does not require any cooling (ie. No cryogens or helium), plumbing, or auxiliary power supplies.  These features significantly reduce operational costs, require far less maintenance and allow quick and easy installation with minimal demand on the laboratory. It has small footprint and due to the negligible fringe field. Any other laboratory equipment can operate right next to it without additional RF or magnetic shielding. It is even compatible with standard laboratory and personal electronic equipment such as mobile phones and laptops.

Further Information

Related Scientific Literature

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