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Publications

Selected peer reviewed scientific publications citing preclinical imaging systems designed, developed and manufactured by Mediso.

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Application Publications
E.Publ. Open Access Bibliography PDF Product(s) Blog Post
Jan-17  

Busk, M. et al. FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach. Acta Oncologica 0, 1–10 (2017) PubMed

Tumor FDG retention normalized to brain signal (T/B) improved scan reproducibility and was superior to traditional SUV quantification in i.v. tracer-injected animals)

  nanoScan PET/MRI  
 Dec-16  Open Access Article

Liu, X. et al. Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts. Oncotarget 8, 6364–6375 (2016).

Development of novel anti-EGFRvIII monoclonal antibody 4G1 and ImmunoSPECT/CT imaging of 125I-4G1 in epidermal growth factor receptor mutant III (EGFRvIII) positive/negative tumor-bearing mice (nS SPECT/CT at Peking University, Beijing, China)

Download in PDF format nanoScan SPECT/CT  
Dec-16 Open Access Article

Ziegler, M. et al. Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets. Scientific Reports 6, 38161 (2016).

Diagnosis of minimal cardiac ischemia with non-invasive molecular PET imaging of activated platelets using newly generated scFvanti-GPIIb/IIIa-64CuMeCOSar radiotracer (nS PET/CT at Monash University, Australia)

Download in PDF format nanoScan PET/CT  
Oct-16 Open Access Article

Edmonds, S. et al. Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines. ACS Nano (2016). doi:10.1021/acsnano.6b05935 PubMed

Tracking liposomal drugs using PET imaging with 89Zr-PLA in a model of metastatic breast and ovarian cancer (nS PET/CT at King's College, London, UK).

Download in PDF format nanoScan PET/CT NanoSPECT/CT Silver Upgrade Related Blog Post
Dec-15   Yu, X. et al. Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer. Radiology 150090 (2015). PubMed (99mTc-3PRGD2, integrin αvβ3-specific)   nanoScan SPECT/CT  
Oct-15 Open Access Article Carney, B. et al. Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. Mol Imaging Biol 1–7 (2015). PubMed Download in PDF format nanoScan PET/MRI Related Blog Post
Sept-15   Gao, L. et al. Molecular imaging of post-Src-inhibition tumor signatures for guiding dasatinib combination therapy. J. Nucl. Med. (2015). PubMed (99mTc-3PRGD2, integrin αvβ3-specific)   nanoScan SPECT/CT  
Jul-15 Open Access Article

Irkle, A. et al. Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography. Nature Communications 6, 7495 (2015).

A radioactive agent developed in the 1960s to detect bone cancer can be re-purposed to highlight the build-up of unstable calcium deposits in arteries, a process that can cause heart attack and stroke (nS PET/CT at University of Cambridge, UK).

  nanoScan PET/CT
Jul-15  

Sander, K. et al. Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. J. Med. Chem. 58, 6058–6080 (2015).

Developed PET tracer showed excellent initial brain uptake and clean conversion to the desired metabolite. Results provide proof-of-concept for development of pro-drug tracers for imaging of P-gp/BCRP function in vivo (nS PET/CT at University College London, UK).

  nanoScan PET/CT  
May-15 Open Access Article Tóth, M. et al. Positron Emission Tomography studies with [11C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation. PLoS ONE 10, e0125917 (2015). PubMed   nanoScan PET/MRI nanoScan PET/CT  
Apr-15 Open Access Article Rodriguez-Vieitez, E. et al. Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study. Eur J Nucl Med Mol Imaging 42, 1119–1132 (2015). PubMed Download in PDF format nanoScan PET/MRI nanoScan PET/CT  
Mar-15 Open Access Article

Mills, B. et al. [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections. EJNMMI Res 5, (2015).

Modified [18F]FDG by phosphorylation to [18F]FDG-6-P to facilitate specific update and accumulation by Staphylococcus aureus and at the site of known infection radiopharmaceutical levels were elevated compared with uninfected controls.

  nanoScan PET/CT  
Jan-15   Tóth, M. et al. Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [11C]T-773. Mol Imaging Biol 17, 445–449 (2015). PubMed   nanoScan PET/MRI nanoScan PET/CT  
Nov-14 Open Access Article Tóth, M. et al. ABC transporter-dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig. EJNMMI Res 4, (2014).
PubMed
  nanoScan PET/MRI nanoScan PET/CT  
Oct-14 Open Access Article

Fack, F. et al. Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol 129, 115–131 (2015).

Glioma anti-angiogenic therapy effects gone astray (anaerobic metabolism induction) monitored by multiple means including nanoScan PET/CT of Mediso by the Norwegian Haukeland Hospital, Bergen University Bergen Norway

Download in PDF format nanoScan PET/CT  
Oct-14   Ma, M. T. et al. Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: comparison with desferrioxamine-B. Dalton Trans. (2014). doi:10.1039/C4DT02978J PubMed   nanoScan PET/CT  
Oct-14   Gnad, T. et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature advance online publication, (2014) PubMed   nanoScan PET/MRI Related Blog Post
Oct-14 Open Access Article Charoenphun, P. et al. [89Zr]Oxinate4 for long-term in vivo cell tracking by positron emission tomography. EJNMMI (2014). doi:10.1007/s00259-014-2945-x PubMed Download in PDF format nanoScan PET/CT NanoSPECT/CT Silver Upgrade Related Blog Post
Sep-14 Open Access Article Botz, B. et al. Differential Regulatory Role of Pituitary Adenylate Cyclase–Activating Polypeptide in the Serum-Transfer Arthritis Model. Arthritis & Rheumatology 66, 2739–2750 (2014). PubMed   nanoScan PET/MRI  
Sep-14   Kovács, M. et al. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med 211, 1993–2011 (2014). PubMed   NanoSPECT/CT Silver Upgrade  
Jul-14   Cui, X. et al. Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials doi:10.1016/j.biomaterials.2014.04.004 PubMed   nanoScan PET/MRI nanoScan PET/CT Related Blog Post
Mar-14 Open Access Article Fülöp, A. et al. Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver. PLoS ONE 9, e90760 (2014).   nanoScan PET/MRI  
Mar-14 Open Access Article Kampmeier, F., Williams, J. D., Maher, J., Mullen, G. E. & Blower, P. J. Design and preclinical evaluation of a 99mTc-labelled diabody of mAb J591 for SPECT imaging of prostate-specific membrane antigen (PSMA). EJNMMI Research 4, 13 (2014). PubMed   NanoSPECT/CT Silver Upgrade  
Jan-14   Cunha, L., Szigeti, K., Mathé, D. & Metello, L. F. The role of molecular imaging in modern drug development. Drug Discovery Today 19, 936–948 (2014). PubMed   nanoScan PET/MRI nanoScan SPECT/CT  
Oct-13   Cunha, L. et al. Preclinical Imaging: an Essential Ally in Modern Biosciences. Mol Diagn Ther 1–21 doi:10.1007/s40291-013-0062-3 PubMed   nanoScan PET/MRI nanoScan SPECT/CT Related Blog Post
Aug-13   Veres, D. S. et al. Quantitative Liver Lesion Volume Determination by Nanoparticle-Based SPECT. Mol Imaging Biol 16, 167–172 (2014). PubMed   NanoSPECT/CT Silver Upgrade  

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Technical Publications
E.Publ. Open Access Bibliography PDF Product(s) Blog Post
Aug-13 Open Access Article Nagy, K. et al. Performance Evaluation of the Small-Animal nanoScan PET/MRI System. J Nucl Med jnumed.112.119065 (2013). doi:10.2967/jnumed.112.119065 PubMed Download in PDF format nanoScan PET/MRI Related Blog Post
Sep-12   Bandi, P. et al. Automated material map generation from MRI scout pairs for preclinical PET attenuation correction. in Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE 5351–5354 (2012). PubMed   nanoScan PET/MRI  
Oct-11   Magdics, M. et al. Performance evaluation of scatter modeling of the GPU-based ‘Tera-Tomo’ 3D PET reconstruction. in 2011 IEEE Nuclear Science Symposium Conference Record 4086–4088 (2011). doi:10.1109/NSSMIC.2011.6153777      
Oct-11   Szanda, I. et al. National Electrical Manufacturers Association NU-4 performance evaluation of the PET component of the NanoPET/CT preclinical PET/CT scanner. J. Nucl. Med. 52, 1741–1747 (2011). PubMed   nanoScan PET  
Apr-11   Magdics, M. & Szirmay-Kalos, L. Crystal Scattering Simulation for PET on the GPU. in 61–64 (The Eurographics Association, 2011).   nanoScan PET  
Nov-10   Hesz, G., Volgyes, D., Benyo, B., Bukki, T. & Major, P. Timing calibration method for NanoPET/CT system. in 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) 2848–2850 (2010). doi:10.1109/NSSMIC.2010.5874314   nanoScan PET  
Nov-10   Lantos, J., Czifrus, S., Legrady, D. & Cserkaszky, A. Detector response function of the NanoPET/CT system. in 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) 3641–3643 (2010). doi:10.1109/NSSMIC.2010.5874491   nanoScan PET  
Oct-09   Jakab, G., Racz, A., Major, P., Bukki, T. & Nemeth, G. Fully GPU based real time corrections and reconstruction for cone beam micro CT. in 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) 4068–4071 (IEEE, 2009). doi:10.1109/NSSMIC.2009.5402403   nanoScan CT  
Oct-09   Major, P. et al. Local energy scale map for NanoPET/CT system. in 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) 3177–3180 (2009). doi:10.1109/NSSMIC.2009.5401698   nanoScan PET  

 

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